Sick building syndrome (SBS) is a combination of health problems associated with an individual's home, office or other building due to the pollutants related to poor indoor air quality, and can be caused by mold, radon, smoke or any number of chemical pollutants.

In some cases, building occupants complain of sick building syndrome symptoms that can include headache, nausea, fever, dizziness, eye or skin irritation, dry cough or fatigue. These symptoms may lessen or disappear when occupants are outside the building.

Sick building syndrome can be controlled or eliminated by removing the source of the contamination, improving ventilation, air filtration and purification.

In 1984 World Health Organization report into the syndrome suggested up to 30% of new and remodeled buildings worldwide may be linked to symptoms of SBS.